Elevated blood pressure response to acute angiotensin Ⅱ infusion in mice lacking membrane-associated prostaglandin E2 synthase-1
Prostaglandin E2(PGE2) plays important roles in blood pressure regulation via modulation of vascular tone and water and sodium homeostasis.Multiple enzymes are involved in PGE2 biosynthesis including the well characterized PGE2 terminal synthase,membrane-associated prostaglandin E2 synthase-1(mPGES-1).The present study was designed to examine the role of mPGES-1 in blood pressure regulation.mPGES-1 was present in both elastic(thoracic aorta) and resistant(mesenteric arteriole) vessels and in kidney.Immun...
- 作者：
- BREYER Matthew M
- 作者单位：
- Division of Nephrology
- 母体文献：
- Proceedings of the Beijing Joint Conference of Physiological Sciences 2008
- 会议名称：
- 2008北京国际生理科学学术大会
- 会议地点：
- 中国北京
- 主办单位：
- 中国科学院上海生命科学研究院；中国生理学会
- 中图分类号：
- R341