Interleukin 10 isoform il-10delta3 stimulated thl-cell specific cytokine gene expression in leukemic cells
Purpose:The pleiotropic interleukin (IL - ) 10 has been shown to enhance the proliferation of malignant B -cells while suppressing T - cell immune responses. Beside expressing the full length IL - 10 transcript, the majority of leukemic cells from patients with first relapse of ALL (75%, 74/98) express a shorter, alternatively spliced transcript lacking exon 3 (termed IL - 10delta3 ), Moreover, the expression of this splice variant is associated with a significantly better probability of event - free s...
- 作者：
- Guenter Henze；Karlheinz Seeger；Reinhard Gessner
- 作者单位：
- Department of Pediatric Oncology/Hematology；Department of Pediatric Oncology/Hematology；Institute of Laboratory Medicine and Biochemistry
- 母体文献：
- 中国首届国际食管癌学术会议暨第七届全国食管癌学术会议论文集
- 会议名称：
- 中国首届国际食管癌学术会议暨第七届全国食管癌学术会议
- 会议地点：
- 中国郑州
- 主办单位：
- 河南省抗癌协会；河南省肿瘤研究所；河南省肿瘤医院；郑州大学医学院；中国抗癌协会食管癌专业委员会；中国医学科学院肿瘤研究所·肿瘤医院
- 中图分类号：
- R733.7